Biochemical model reactions indicative of inflammatory processes. Activities of extracts from Fraxinus excelsior and Populus tremula.
Identifieur interne : 004833 ( Main/Exploration ); précédent : 004832; suivant : 004834Biochemical model reactions indicative of inflammatory processes. Activities of extracts from Fraxinus excelsior and Populus tremula.
Auteurs : H. Schempp [Allemagne] ; D. Weiser ; E F ElstnerSource :
- Arzneimittel-Forschung [ 0004-4172 ] ; 2000.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Antioxydants (usage thérapeutique), Cellules cultivées (MeSH), Chromatographie en phase liquide à haute performance (MeSH), Enzymes (métabolisme), Extraits de plantes (pharmacologie), Humains (MeSH), Indicateurs et réactifs (MeSH), Inflammation (anatomopathologie), Lipoprotéines LDL (métabolisme), Lipoxygenase (métabolisme), Maladies de l'appareil respiratoire (anatomopathologie), Maladies de l'appareil respiratoire (traitement médicamenteux), Maladies du système nerveux (anatomopathologie), Maladies du système nerveux (traitement médicamenteux), Maladies inflammatoires intestinales (anatomopathologie), Maladies inflammatoires intestinales (traitement médicamenteux), Modèles biologiques (MeSH), Myeloperoxidase (métabolisme), Piégeurs de radicaux libres (pharmacologie), Plantes médicinales (composition chimique), Stimulation du métabolisme oxydatif (effets des médicaments et des substances chimiques), Stress oxydatif (effets des médicaments et des substances chimiques), Tyrosine (analogues et dérivés), Tyrosine (métabolisme), Xanthine oxidase (métabolisme).
- MESH :
- analogues et dérivés : Tyrosine.
- anatomopathologie : Inflammation, Maladies de l'appareil respiratoire, Maladies du système nerveux, Maladies inflammatoires intestinales.
- composition chimique : Plantes médicinales.
- effets des médicaments et des substances chimiques : Stimulation du métabolisme oxydatif, Stress oxydatif.
- métabolisme : Enzymes, Lipoprotéines LDL, Lipoxygenase, Myeloperoxidase, Tyrosine, Xanthine oxidase.
- pharmacologie : Extraits de plantes, Piégeurs de radicaux libres.
- traitement médicamenteux : Maladies de l'appareil respiratoire, Maladies du système nerveux, Maladies inflammatoires intestinales.
- usage thérapeutique : Antioxydants.
- Animaux, Cellules cultivées, Chromatographie en phase liquide à haute performance, Humains, Indicateurs et réactifs, Modèles biologiques.
English descriptors
- KwdEn :
- Animals (MeSH), Antioxidants (therapeutic use), Cells, Cultured (MeSH), Chromatography, High Pressure Liquid (MeSH), Enzymes (metabolism), Free Radical Scavengers (pharmacology), Humans (MeSH), Indicators and Reagents (MeSH), Inflammation (pathology), Inflammatory Bowel Diseases (drug therapy), Inflammatory Bowel Diseases (pathology), Lipoproteins, LDL (metabolism), Lipoxygenase (metabolism), Models, Biological (MeSH), Nervous System Diseases (drug therapy), Nervous System Diseases (pathology), Oxidative Stress (drug effects), Peroxidase (metabolism), Plant Extracts (pharmacology), Plants, Medicinal (chemistry), Respiratory Burst (drug effects), Respiratory Tract Diseases (drug therapy), Respiratory Tract Diseases (pathology), Tyrosine (analogs & derivatives), Tyrosine (metabolism), Xanthine Oxidase (metabolism).
- MESH :
- chemical , analogs & derivatives : Tyrosine.
- chemical , metabolism : Enzymes, Lipoproteins, LDL, Lipoxygenase, Peroxidase, Tyrosine, Xanthine Oxidase.
- chemical , pharmacology : Free Radical Scavengers, Plant Extracts.
- chemical , therapeutic use : Antioxidants.
- chemistry : Plants, Medicinal.
- drug effects : Oxidative Stress, Respiratory Burst.
- drug therapy : Inflammatory Bowel Diseases, Nervous System Diseases, Respiratory Tract Diseases.
- pathology : Inflammation, Inflammatory Bowel Diseases, Nervous System Diseases, Respiratory Tract Diseases.
- Animals, Cells, Cultured, Chromatography, High Pressure Liquid, Humans, Indicators and Reagents, Models, Biological.
Abstract
All processes of oxygen activation include very reactive intermediates. Therefore, aerobic cells must cope with--and to some extent also adapt to--oxidative stress provoked for example by infections or intoxications, where these reactive intermediates accumulate. All inflammatory processes include such oxygen activating processes where reactive oxygen species (ROS) are produced. Dependent on the strength of these impact(s), several symptoms indicate the deviation from normal, steady-state metabolism. Intrinsic radical scavenging processes or compounds administered with food thus have to warrant metabolic control within certain limits. Antioxidants which in many cases are free radical scavengers or quenchers of activated states comprise a vast number of classes of organic molecules including phenolics as the most prominent ones. In this publication the activities of extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea as components of the drug Phytodolor and their mechanisms of protection from oxidative damage are summarized. In addition, new results on tyrosine nitration, a process characteristic for sites of inflammation, and its inhibition by these plant extracts, is reported.
DOI: 10.1055/s-0031-1300215
PubMed: 10800635
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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à haute performance</term><term>Humains</term><term>Indicateurs et réactifs</term><term>Modèles biologiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">All processes of oxygen activation include very reactive intermediates. Therefore, aerobic cells must cope with--and to some extent also adapt to--oxidative stress provoked for example by infections or intoxications, where these reactive intermediates accumulate. All inflammatory processes include such oxygen activating processes where reactive oxygen species (ROS) are produced. Dependent on the strength of these impact(s), several symptoms indicate the deviation from normal, steady-state metabolism. Intrinsic radical scavenging processes or compounds administered with food thus have to warrant metabolic control within certain limits. Antioxidants which in many cases are free radical scavengers or quenchers of activated states comprise a vast number of classes of organic molecules including phenolics as the most prominent ones. In this publication the activities of extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea as components of the drug Phytodolor and their mechanisms of protection from oxidative damage are summarized. In addition, new results on tyrosine nitration, a process characteristic for sites of inflammation, and its inhibition by these plant extracts, is reported.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10800635</PMID><DateCompleted><Year>2000</Year><Month>06</Month><Day>09</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0004-4172</ISSN><JournalIssue CitedMedium="Print"><Volume>50</Volume><Issue>4</Issue><PubDate><Year>2000</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Arzneimittel-Forschung</Title><ISOAbbreviation>Arzneimittelforschung</ISOAbbreviation></Journal><ArticleTitle>Biochemical model reactions indicative of inflammatory processes. Activities of extracts from Fraxinus excelsior and Populus tremula.</ArticleTitle><Pagination><MedlinePgn>362-72</MedlinePgn></Pagination><Abstract><AbstractText>All processes of oxygen activation include very reactive intermediates. Therefore, aerobic cells must cope with--and to some extent also adapt to--oxidative stress provoked for example by infections or intoxications, where these reactive intermediates accumulate. All inflammatory processes include such oxygen activating processes where reactive oxygen species (ROS) are produced. Dependent on the strength of these impact(s), several symptoms indicate the deviation from normal, steady-state metabolism. Intrinsic radical scavenging processes or compounds administered with food thus have to warrant metabolic control within certain limits. Antioxidants which in many cases are free radical scavengers or quenchers of activated states comprise a vast number of classes of organic molecules including phenolics as the most prominent ones. In this publication the activities of extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea as components of the drug Phytodolor and their mechanisms of protection from oxidative damage are summarized. 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Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Arzneimittelforschung</MedlineTA><NlmUniqueID>0372660</NlmUniqueID><ISSNLinking>0004-4172</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004798">Enzymes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016166">Free Radical Scavengers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007202">Indicators and Reagents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008077">Lipoproteins, LDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>3604-79-3</RegistryNumber><NameOfSubstance UI="C002744">3-nitrotyrosine</NameOfSubstance></Chemical><Chemical><RegistryNumber>42HK56048U</RegistryNumber><NameOfSubstance UI="D014443">Tyrosine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.11.1.7</RegistryNumber><NameOfSubstance UI="D009195">Peroxidase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.13.11.12</RegistryNumber><NameOfSubstance UI="D008084">Lipoxygenase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.17.3.2</RegistryNumber><NameOfSubstance UI="D014969">Xanthine Oxidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004798" MajorTopicYN="N">Enzymes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016166" MajorTopicYN="N">Free Radical Scavengers</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007202" MajorTopicYN="N">Indicators and Reagents</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015212" MajorTopicYN="N">Inflammatory Bowel Diseases</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008077" MajorTopicYN="N">Lipoproteins, LDL</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008084" MajorTopicYN="N">Lipoxygenase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009422" MajorTopicYN="N">Nervous System Diseases</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009195" MajorTopicYN="N">Peroxidase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010946" MajorTopicYN="N">Plants, Medicinal</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016897" MajorTopicYN="N">Respiratory Burst</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012140" MajorTopicYN="N">Respiratory Tract Diseases</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014443" MajorTopicYN="N">Tyrosine</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014969" MajorTopicYN="N">Xanthine Oxidase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year><Month>5</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2000</Year><Month>6</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2000</Year><Month>5</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10800635</ArticleId><ArticleId IdType="doi">10.1055/s-0031-1300215</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement><orgName><li>Université technique de Munich</li></orgName></list><tree><noCountry><name sortKey="Elstner, E F" sort="Elstner, E F" uniqKey="Elstner E" first="E F" last="Elstner">E F Elstner</name><name sortKey="Weiser, D" sort="Weiser, D" uniqKey="Weiser D" first="D" last="Weiser">D. Weiser</name></noCountry><country name="Allemagne"><region name="Bavière"><name sortKey="Schempp, H" sort="Schempp, H" uniqKey="Schempp H" first="H" last="Schempp">H. Schempp</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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